{"id":14576,"date":"2026-09-19T09:50:40","date_gmt":"2026-09-19T08:50:40","guid":{"rendered":"https:\/\/www.bioteckacademy.com\/?p=14576"},"modified":"2026-09-19T09:50:40","modified_gmt":"2026-09-19T08:50:40","slug":"heterologous-biomaterials-collagen-beta-tcp-in-vitro-study","status":"publish","type":"post","link":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/","title":{"rendered":"When collagen makes the difference: a comparative In Vitro study of heterologous biomaterials containing different forms of collagen and \u03b2-TCP"},"content":{"rendered":"\r\n<p class=\"wp-block-paragraph\">We are pleased to announce the publication of a new Bioteck Academy Sheet summarizing a recently published <em>in vitro<\/em> study in the international journal <em>Minerva Dental and Oral Science.<\/em><\/p>\r\n<p>&nbsp;<\/p>\r\n\r\n\r\n<p class=\"wp-block-paragraph\">The study, conducted at the laboratories of San Raffaele Hospital in Milan and coordinated by Prof. Danilo Alessio Di Stefano, president-elect of the IAO, evaluated the biological behavior of two equine-derived bone substitutes by comparing them with a synthetic biomaterial based on \u03b2-tricalcium phosphate (\u03b2-TCP).<\/p>\r\n\r\n\r\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\r\n<p>The equine biomaterials analyzed consisted of a graft containing <strong>preserved native collagen (Osteoplant\u00ae\/Osteoxenon\u00ae)<\/strong> and a graft containing <strong>hydrolyzed collagen (Bio-Gen\u00ae)<\/strong>, both obtained through the <strong>Zymo-Teck\u00ae <\/strong>temperature-controlled enzymatic deantigenation process, patented by <strong>Bioteck SpA.<\/strong><\/p>\r\n\r\n\r\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\r\n<p>The materials were tested <em>in vitro<\/em>, evaluating key aspects such as cell viability, adhesion capacity, osteogenic differentiation potential, and the expression of genes involved in bone formation and remodeling processes.<\/p>\r\n\r\n\r\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\r\n<p>The results showed a limited biological response in cells exposed to \u03b2-TCP, while those cultured on equine biomaterials exhibited greater osteogenic activity, with varying levels of cellular differentiation. In particular, the biomaterial containing preserved collagen demonstrated the greatest ability to support osteoblast maturation and stimulate the biological mechanisms associated with bone regeneration.<\/p>\r\n\r\n\r\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\r\n<p><a href=\"https:\/\/www.bioteckacademy.com\/wp-content\/uploads\/2026\/07\/RES_SCH6_EN_web.pdf\">Read the full profile here!<\/a><\/p>\r\n<p>&nbsp;<\/p>\r\n<p><strong>Want to learn more? You can find us at the IAO Congress from October 8 to 10 in Padua and at the TRAUMAMEETING in Riccione from October 7 to 9!<\/strong><\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>We are pleased to announce the publication of a new Bioteck Academy Sheet summarizing a recently published in vitro study in the international journal Minerva Dental and Oral [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":14578,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-14576","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Collagen and \u03b2-TCP in heterologous biomaterials: in vitro study<\/title>\n<meta name=\"description\" content=\"An in vitro study compares heterologous biomaterials containing preserved or hydrolyzed collagen with \u03b2-TCP, evaluating cellular responses.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Collagen and \u03b2-TCP in heterologous biomaterials: in vitro study\" \/>\n<meta property=\"og:description\" content=\"An in vitro study compares heterologous biomaterials containing preserved or hydrolyzed collagen with \u03b2-TCP, evaluating cellular responses.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Bioteck Academy\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-19T08:50:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.bioteckacademy.com\/wp-content\/uploads\/2026\/09\/SCH6-social-EN-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1109\" \/>\n\t<meta property=\"og:image:height\" content=\"578\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"gs_laziendinacreativa\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"gs_laziendinacreativa\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/\"},\"author\":{\"name\":\"gs_laziendinacreativa\",\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/#\\\/schema\\\/person\\\/2e41e884214f64b193a0db301fa9c994\"},\"headline\":\"When collagen makes the difference: a comparative In Vitro study of heterologous biomaterials containing different forms of collagen and \u03b2-TCP\",\"datePublished\":\"2026-09-19T08:50:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/\"},\"wordCount\":247,\"image\":{\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.bioteckacademy.com\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/SCH6-featured-EN.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/\",\"url\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/\",\"name\":\"Collagen and \u03b2-TCP in heterologous biomaterials: in vitro study\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.bioteckacademy.com\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/SCH6-featured-EN.jpg\",\"datePublished\":\"2026-09-19T08:50:40+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/#\\\/schema\\\/person\\\/2e41e884214f64b193a0db301fa9c994\"},\"description\":\"An in vitro study compares heterologous biomaterials containing preserved or hydrolyzed collagen with \u03b2-TCP, evaluating cellular responses.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.bioteckacademy.com\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/SCH6-featured-EN.jpg\",\"contentUrl\":\"https:\\\/\\\/www.bioteckacademy.com\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/SCH6-featured-EN.jpg\",\"width\":1118,\"height\":574,\"caption\":\"When collagen makes the difference: a comparative In Vitro study of heterologous biomaterials containing different forms of collagen and \u03b2-TCP - immagine in evidenza EN\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"When collagen makes the difference: a comparative In Vitro study of heterologous biomaterials containing different forms of collagen and \u03b2-TCP\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/\",\"name\":\"Bioteck Academy\",\"description\":\"La Bioteck Academy promuove la diffusione del sapere nel campo della medicina rigenerativa applicata all\u2019odontoiatria, alla chirurgia maxillofacciale, all\u2019ortopedia e alla neurochirurgia.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/#\\\/schema\\\/person\\\/2e41e884214f64b193a0db301fa9c994\",\"name\":\"gs_laziendinacreativa\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/4e8f8b41164f6afc31fe7fc0fc8292f68d076213f1e34cc242397d8a6b05c81d?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/4e8f8b41164f6afc31fe7fc0fc8292f68d076213f1e34cc242397d8a6b05c81d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/4e8f8b41164f6afc31fe7fc0fc8292f68d076213f1e34cc242397d8a6b05c81d?s=96&d=mm&r=g\",\"caption\":\"gs_laziendinacreativa\"},\"url\":\"https:\\\/\\\/www.bioteckacademy.com\\\/en\\\/author\\\/gs_laziendinacreativa\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Collagen and \u03b2-TCP in heterologous biomaterials: in vitro study","description":"An in vitro study compares heterologous biomaterials containing preserved or hydrolyzed collagen with \u03b2-TCP, evaluating cellular responses.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/","og_locale":"en_US","og_type":"article","og_title":"Collagen and \u03b2-TCP in heterologous biomaterials: in vitro study","og_description":"An in vitro study compares heterologous biomaterials containing preserved or hydrolyzed collagen with \u03b2-TCP, evaluating cellular responses.","og_url":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/","og_site_name":"Bioteck Academy","article_published_time":"2026-09-19T08:50:40+00:00","og_image":[{"width":1109,"height":578,"url":"https:\/\/www.bioteckacademy.com\/wp-content\/uploads\/2026\/09\/SCH6-social-EN-1.jpg","type":"image\/jpeg"}],"author":"gs_laziendinacreativa","twitter_card":"summary_large_image","twitter_misc":{"Written by":"gs_laziendinacreativa","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/#article","isPartOf":{"@id":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/"},"author":{"name":"gs_laziendinacreativa","@id":"https:\/\/www.bioteckacademy.com\/en\/#\/schema\/person\/2e41e884214f64b193a0db301fa9c994"},"headline":"When collagen makes the difference: a comparative In Vitro study of heterologous biomaterials containing different forms of collagen and \u03b2-TCP","datePublished":"2026-09-19T08:50:40+00:00","mainEntityOfPage":{"@id":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/"},"wordCount":247,"image":{"@id":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/#primaryimage"},"thumbnailUrl":"https:\/\/www.bioteckacademy.com\/wp-content\/uploads\/2026\/09\/SCH6-featured-EN.jpg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/","url":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/","name":"Collagen and \u03b2-TCP in heterologous biomaterials: in vitro study","isPartOf":{"@id":"https:\/\/www.bioteckacademy.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/#primaryimage"},"image":{"@id":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/#primaryimage"},"thumbnailUrl":"https:\/\/www.bioteckacademy.com\/wp-content\/uploads\/2026\/09\/SCH6-featured-EN.jpg","datePublished":"2026-09-19T08:50:40+00:00","author":{"@id":"https:\/\/www.bioteckacademy.com\/en\/#\/schema\/person\/2e41e884214f64b193a0db301fa9c994"},"description":"An in vitro study compares heterologous biomaterials containing preserved or hydrolyzed collagen with \u03b2-TCP, evaluating cellular responses.","breadcrumb":{"@id":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/#primaryimage","url":"https:\/\/www.bioteckacademy.com\/wp-content\/uploads\/2026\/09\/SCH6-featured-EN.jpg","contentUrl":"https:\/\/www.bioteckacademy.com\/wp-content\/uploads\/2026\/09\/SCH6-featured-EN.jpg","width":1118,"height":574,"caption":"When collagen makes the difference: a comparative In Vitro study of heterologous biomaterials containing different forms of collagen and \u03b2-TCP - immagine in evidenza EN"},{"@type":"BreadcrumbList","@id":"https:\/\/www.bioteckacademy.com\/en\/heterologous-biomaterials-collagen-beta-tcp-in-vitro-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.bioteckacademy.com\/en\/"},{"@type":"ListItem","position":2,"name":"When collagen makes the difference: a comparative In Vitro study of heterologous biomaterials containing different forms of collagen and \u03b2-TCP"}]},{"@type":"WebSite","@id":"https:\/\/www.bioteckacademy.com\/en\/#website","url":"https:\/\/www.bioteckacademy.com\/en\/","name":"Bioteck Academy","description":"La Bioteck Academy promuove la diffusione del sapere nel campo della medicina rigenerativa applicata all\u2019odontoiatria, alla chirurgia maxillofacciale, all\u2019ortopedia e alla neurochirurgia.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.bioteckacademy.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.bioteckacademy.com\/en\/#\/schema\/person\/2e41e884214f64b193a0db301fa9c994","name":"gs_laziendinacreativa","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/4e8f8b41164f6afc31fe7fc0fc8292f68d076213f1e34cc242397d8a6b05c81d?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/4e8f8b41164f6afc31fe7fc0fc8292f68d076213f1e34cc242397d8a6b05c81d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/4e8f8b41164f6afc31fe7fc0fc8292f68d076213f1e34cc242397d8a6b05c81d?s=96&d=mm&r=g","caption":"gs_laziendinacreativa"},"url":"https:\/\/www.bioteckacademy.com\/en\/author\/gs_laziendinacreativa\/"}]}},"_links":{"self":[{"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/posts\/14576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/comments?post=14576"}],"version-history":[{"count":3,"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/posts\/14576\/revisions"}],"predecessor-version":[{"id":14594,"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/posts\/14576\/revisions\/14594"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/media\/14578"}],"wp:attachment":[{"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/media?parent=14576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/categories?post=14576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bioteckacademy.com\/en\/wp-json\/wp\/v2\/tags?post=14576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}