Osteoplant is an equine cortical and spongy bone tissue, used to fill bone defects in orthopedic, maxillofacial and dental surgery. To study the mechanism by which Osteoplant induces the reabsorption and the substitution of the graft with new bone, the expression of genes related to the osteoblast differentiation were analyzed using cultures of stem cells derived from adipose tissue treated with Osteoplant. Gene expression profile, obtained with real time Reverse Transcription-Polymerase Chain Reaction demonstrated that Osteoplant influences the differentiation of adipose derived stem cells by the activation of bone related genes like osteopontin (SPP1) and alkaline phosphatase (ALPL).
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