The article presents a clinical case of a 60-year-old man with distal 4-quadrant edentulism. Specifically, the patient came to the attention of the surgeon as a result of excessive mobility and apical migration of the metal-ceramic bridge at the level of elements 13-15. Following clinical and radiographic investigation, a vestibular bone deficit of 6mm was observed at site 13, and rehabilitation of site 16 required a mini sinus lift. The vestibular bone deficit was treated by GBR and concomitant implant placement at site 13 and 14. Regenerative surgery was performed with heterologous collagen-preserved grafts of equine origin (Osteoxenon Cortical-Cancellous Granules, Bioteck Spa, Arcugnano – Vicenza), covered and protected by a 0.5-mm-thick flexible cortical bone sheet (Osteoxenon Flex Cortical Sheet, Bioteck Spa, Arcugnano – Vicenza).