EQUINE BONE SUBSTITUTES IN GUIDED BONE REGENERATION OF A SEGMENTAL DEFECT

In-vivo comparison of autologous and heterologous bone grafts in rat femur bone regeneration

The report presents the results of a study in which 30 albino Wistar male rats underwent Guided Bone Regeneration (GBR) following the creation of a segmental defect along the femoral diaphysis surgically. The rats were distributed in 3 groups depending on the biomaterial used: a negative control group (GN) in which the segmental defect was not filled; a positive control group (GP) in which the defect was filled with fragmented autologous bone; a group (GE) in which the defect was filled with equine bone substitutes (Bio-Gen, Bioteck). The study showed that the use of equine grafts is associated with a significant increase in bone volume and mineral density from the first 2 weeks after GBR surgery. 

PRODUCTS USED: Bio-Gen Granules Mix, Biocollagen Membrane