The aim is to show the treatment effect of the biofilm decontamination approach on acute periodontal abscess and peri-implantitis. A periodontal abscess and a peri-implantitis were treated using an oral tissue desiccation material that contains a concentrated aqueous mixture of hydroxybenzenesulfonic and hydroxymethoxybenzene acids and sulfuric acid. The material was positioned in the periodontal pockets and around the implant. No systemic or local antibiotics were used in any of the cases. All of the treated cases healed well and very rapidly. The infections were quickly resolved without complications. The momentary pain upon introduction of the material was generally well tolerated and it completely disappeared after few seconds. The biofilm desiccation approach seems to be a very promising technique for the treatment of acute periodontal abscess and peri-implantitis. The local application of this material avoids the use of systemic or local antibiotics.