Reliable implant-supported rehabilitation of an alveolar ridge requires proper quality and quantity of alveolar bone at the implant site. In order to achieve a prosthetic-driven positioning, bone augmentation techniques may be required. Guided bone regeneration (GBR) procedures call for the use of barrier membrane to isolate the regenerating site, thus facilitating bone-regenerative events by means of surrounding soft tissue exclusion. Since the introduction of this technique, a number of membrane materials have been employed. Recently, an enzyme-deantigenic, flexible equine cortical bone membrane has been designed for regenerative surgery. The aim of this work was to test the effectiveness of using the membrane in conjunction with enzyme-deantigenic bone granules for a GBR procedure performed to restore vertical and horizontal bony defects with simultaneous implant placement. The patient was successfully rehabilitated. Two years after surgery, the implants were perfectly functional, and the peri-implant bone level was stable over time as shown by radiographic analysis.