Effect of bone graft biomaterials at different chemical composition and geometry on human Bone Marrow Stromal Cells osteogenic differentiation
For the repair of bone defects, a tissue engineering approach would be to combine cells capable of osteogenic (i.e. bone forming) activity with an appropriate scaffolding material to stimulate bone regeneration and repair.
Bone Graft Materials (BGMs) constitute an essential adjuvant for bone tissue regeneration in oral surgeries to achieve ostheosynthesis, bone augmentation and implant osseointegration. Human mesenchymal stem cells (hMSCs), when combined with hydroxyapatite/beta-tricalcium phosphate (HA/TCP) ceramic scaffolds have been shown to induce bone formation in large or long bone defects. BGMs are currently used in bone regeneration in oral surgery, therefore the aim of our study was to investigate whether biomaterials with different chemical composition and geometry improve the osteogenic capability of the hMSCs in a site of implant.