Treatment of mandibular atrophy by an equine bone substitute: an immunohistochemical study in man
Objective : To perform an immunohistochemical evaluation of microvessel density (MVD), vascular endothelial growth factor (VEGF) and nitric oxide synthase (NOS) expression in mandibular ridge regeneration using an equine derived bone substitute.
Materials and methods : Ridge augmentations were performed in six patients using equine bone. After a six-month healing period, four bone cores from no augmented (control) and four from augmented sites (test) were retrieved and processed for immunohistochemistry.
Results : Statistically, significant differences were found in the MVD expression between control and test sites (p <0.05). The high and low intensities of VEGF, NOS1 and NOS3 were mainly expressed in test samples with statistical differences with control (p < 0.05).
Conclusions : Within the limits of the small sample size, the present study indicated that equine bone is able to support neovascularization when used as a grafting material.
Pubblicato su Italian Oral Surgery