To evaluate the bone repair process with GenOx and Bio-Gen biomaterials, associated or not to PRP. from the qualitative aspect, six female beagle dogs (2 years-old, 10kg) were used. Six circular bone defects (6mm in diameter} were prepared, being three on the left and three on the right mandibular side. Each cavity on both sides was filled with: Bio-Gen, coagulum (control}, and Gen-Ox, being one side receiving PRP. Samples were collected at 30, 60, and 90 days for histological quantitative analysis at 20x magnification. Bio-Gen+PRP group demonstrated more advanced repair when compared to the other groups. The use of PRP generated secondary bone at all time periods. The equine substitute bone presented the best results regarding mature bone formation, given its efficacy enhanced by PRP.