This clinical case involves a patient with element 17 judged to be unrecoverable due to an endodontic lesion at the mesio-vestibular root, associated with a vertical fracture, and therefore destined for extraction. Following atraumatic avulsion of the element, the socket was filled with cortical-cancellous granules of equine origin protected by a three-dimensional collagen matrix, an excellent substrate for soft tissue growth. Follow-ups at different follow-ups showed soft tissue healing and progressive remodeling of the bone substitute with the patient’s own bone. At 6 months, the bone formation was deemed suitable for implant placement. At the same time, a bone biopsy was taken to evaluate the effectiveness of the bone regeneration procedure from a histological and histomorphometric point of view.