To compare the alveolar bone repair process using biomaterial in six beagles dogs with and without the incorporation of platelet-rich plasma, bilateral extractions of the three mandibular premolars were performed. Bio-Gen granules were applied in the first alveolus, the clot was maintained in the second alveolus and Genox was applied to the third alveolus. PRP was added to all alveoli on the left side only. The dogs were submitted to euthanasia after 30, 60 and 90 days and submitted to histological analysis for the determination of mean area of new bone formation. Significant increase in bone formation occurred in Bio-Gen + PRP when compared with the other groups at 30 and 90 days. The Bio-Gen biomaterial led to the best bone repair and the combination of platelet-rich plasma accelerated the repair process.