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Scientific Research

HYDROLYZED COLLAGEN: AN IN VITRO STUDY

2019
Author : De Luca P., de Girolamo L., Colombini A.

 

The in vitro effects of CHondroGrid, a possible adjuvant in the treatment of osteoarthrosis symptoms. 

The study at first entailed isolation and then expansion in culture of human chondrocytes obtained from donors suffering from arthrosis of the hip. The cells were then exposed to different concentrations of CHondroGrid. The cell viability test showed that CHondroGrid does not have a negative effect on cell viability except in high concentrations (1.5 mg/ml). From a histological point of view, the chondrocytes cultured in a chondrogenic culture medium, in the presence of CHondroGrid, deposited significantly higher quantities of extracellular matrix compared to cells that were neither exposed to CHondroGrid nor were cultured in a chondrogenic medium. These results show that CHondroGrid is intrinsically safe and suggest that its application may induce chondrocytes to produce hyaline articular cartilage, countering the normal reparative response that would lead to the formation of fibrous tissue. 

PRODUCTS USED: CHondroGrid CHG-004 CHG-PK4

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