In the anterior maxilla, where patients typically have the highest expectations for implant-supported restorations, bone resorption consequent to edentulism often leads to a lack of soft tissue support and ultimately to unsatisfactory aesthetic results. When this occurs, buccal bone augmentation following guided bone regeneration principles at the time of implant placement, and appropriate, even incremental. Management of soft tissues may instead guarantee the prosthetic, clinical and aesthetic success. Regeneration is accomplished using a membrane, interposed between the soft tissue and the grafting material, acting as a barrier between the different cell types. The authors have been using since several years a membrane is made of thin, flexible equine cortical bone that is rendered non-antigenic by a collagen-preserving enzymatic process. The aim is to report a successful use of equine enzyme-deantigenic cortical membrane and bone granules for guided bone regeneration in the aesthetic zone concomitant with implant placement. This report describes the treatment of a patient who received an equine enzyme-deantigenic graft and membrane in conjunction with placement of an implant in the upper anterior left maxilla, and careful soft tissue management. The purpose was both that of regenerating the peri-implant bone tissue and that of recovering an appropriate ridge profile, to guarantee implant osseointegration as well as an excellent functional and aesthetic outcome. No intra- or post-surgical complications occurred. After three years, the patient was still very satisfied with her appearance. A CBCT scan showed that the peri-implant bone levels and ridge thickness had been maintained, and possibly a novel physiological cortical ridge layer had been formed. Conclusion: Guided bone regeneration with the concomitant use of enzyme-deantigenic membrane and graft may be a valuable and suitable option for effective implant-supported prosthetic rehabilitations in the aesthetic zone.