News
Editorial Bioteck
19 September 2026
When collagen makes the difference: a comparative In Vitro study of heterologous biomaterials containing different forms of collagen and β-TCP
We are pleased to announce the publication of a new Bioteck Academy Sheet summarizing a recently published in vitro study in the international journal Minerva Dental and Oral Science.
The study, conducted at the laboratories of San Raffaele Hospital in Milan and coordinated by Prof. Danilo Alessio Di Stefano, president-elect of the IAO, evaluated the biological behavior of two equine-derived bone substitutes by comparing them with a synthetic biomaterial based on β-tricalcium phosphate (β-TCP).
The equine biomaterials analyzed consisted of a graft containing preserved native collagen (Osteoplant®/Osteoxenon®) and a graft containing hydrolyzed collagen (Bio-Gen®), both obtained through the Zymo-Teck® temperature-controlled enzymatic deantigenation process, patented by Bioteck SpA.
The materials were tested in vitro, evaluating key aspects such as cell viability, adhesion capacity, osteogenic differentiation potential, and the expression of genes involved in bone formation and remodeling processes.
The results showed a limited biological response in cells exposed to β-TCP, while those cultured on equine biomaterials exhibited greater osteogenic activity, with varying levels of cellular differentiation. In particular, the biomaterial containing preserved collagen demonstrated the greatest ability to support osteoblast maturation and stimulate the biological mechanisms associated with bone regeneration.
Want to learn more? You can find us at the IAO Congress from October 8 to 10 in Padua and at the TRAUMAMEETING in Riccione from October 7 to 9!
