IMMUNOHISTOCHEMICAL STUDY OF EQUINE BONE SUBSTITUTES

The sheet summarizes the results of a study published in Implant Dentistry in 2011. The study used a preserved collagen equine bone substitute (Osteoxenon, Bioteck), consisting of both cancellous and cortical (1:1) bone granules ranging from 0.5 to 1 mm in size. The researchers analyzed bone samples from maxillary sinuses that had received either an autologous bone graft or an 1:1 mixture of autologous bone and Osteoxenon and, as control, samples of bone tissue from under the sinus floor. The histological analyses allowed assessing the Microvessel Density (MVD), a measurement of density of the tissue’s vessels, an indicator – in tissues undergoing regeneration – of tissue neovascularization. Immunohistochemical analyses were carried out on two factors which, in different ways, contribute to the positive modulation of osteogenesis. The results of the study show how Osteoxenon interacts physiologically with regeneration processes, confirming it as a valid alternative to the exclusive use of autologous bone.

PRODUCTS USED: Osteoxenon Granules Mix, Biocollagen Membrane